Alternate Donor HCT for Fanconi Anemia (FA): Results of a Total Body Irradiation (TBI) Dose De-Escalation Study
نویسندگان
چکیده
منابع مشابه
Radiation-free, alternative-donor HCT for Fanconi anemia patients: results from a prospective multi-institutional study.
Fanconi anemia (FA) is an inherited bone marrow failure syndrome characterized by chromosomal fragility, progressive marrow failure, and cancer predisposition. Hematopoietic cell transplantation (HCT) is curative for FA-related marrow failure or leukemia, but both radiation exposure during transplant and graft-versus-host disease (GVHD) may increase risk of later malignancies of the head and ne...
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Total body irradiation (TBI) is a kind of external beam radiotherapy which is used in conjunction with chemotherapy with the purpose of immunosuppression before bone marrow transplantation. As recommended by AAPM dose distribution uniformity in TBI is very important and dose variation must be within ±10% of prescription dose. Patients treatment geometry for TBI techniques fall into two co...
متن کاملdiode calibration for dose determination in total body irradiation
background: total body irradiation (tbi) is different from standard radiotherapy in many aspects, so it is not easy to predict the delivered dose to the patient under tbi treatment. diode dosimetry procedures for surface dose reading can help to define variations of the actually delivered dose from the prescribed one. the aim of this study was to describe the measurements made to calibrate diod...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2009
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2008.12.011